NFE2L3 and NFE2L1

Number of citations of the paper that reports this interaction (PubMedID 23661758)
49

Data Source:
BioGRID (fluorescent resonance energy transfer)

		NFE2L3	NFE2L1
Description		nuclear factor, erythroid 2 like 3	nuclear factor, erythroid 2 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Cholesterol Binding Protein Domain Specific Binding Protein-containing Complex Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription, DNA-templated	Protein Polyubiquitination Fructose 6-phosphate Metabolic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Glutathione Metabolic Process Heme Biosynthetic Process Inflammatory Response Regulation Of Mitotic Nuclear Division Cholesterol Metabolic Process Anatomical Structure Morphogenesis Regulation Of Glucose Metabolic Process Regulation Of Fatty Acid Metabolic Process Cellular Homeostasis Spinal Cord Motor Neuron Differentiation Glial Cell Fate Commitment Erythrocyte Differentiation Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Cholesterol Homeostasis Cysteine Transport Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Glucose 6-phosphate Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Cold Cellular Response To Copper Ion Cellular Response To Cholesterol Regulation Of Nucleus Organization Regulation Of Response To Endoplasmic Reticulum Stress
Pathways
Drugs			Lauryl Dimethylamine-N-Oxide
Diseases
GWAS		Body mass index ( 23583978) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Endometriosis ( 28333195) Gamma glutamyl transferase levels ( 29403010) Height ( 31562340) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 29403010) Obesity-related traits ( 23251661) Phoneme awareness ( 30741946) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Superior frontal gyrus grey matter volume ( 25335168) Total cholesterol levels ( 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Generalized epilepsy ( 22949513) Heel bone mineral density ( 30598549)
Interacting Genes		8 interacting genes: BACH2 CREB3 GSK3B MAFK NFE2 NFE2L1 NFE2L2 PPARG	15 interacting genes: ATF4 BACH2 CAPN1 CD6 CREBZF GSK3B HCFC1 JUN JUNB JUND MAFF MAFG MAFK NFE2L3 PARVA
Entrez ID		9603	4779
HPRD ID		09162	01223
Ensembl ID		ENSG00000050344	ENSG00000082641
Uniprot IDs		Q9Y4A8	J9JIE5 Q14494 Q8NF22
PDB IDs
Enriched GO Terms of Interacting Partners?
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