SEC22B and B3GAT3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SEC22B	B3GAT3
Description		SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)	beta-1,3-glucuronyltransferase 3
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Synaptic Vesicle ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Transport Vesicle COPI-coated Vesicle Phagocytic Vesicle Membrane SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome	Golgi Membrane Golgi Apparatus Cis-Golgi Network Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	SNAP Receptor Activity Protein Binding Syntaxin Binding	Protein Binding Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Activity Glucuronosyltransferase Activity Metal Ion Binding Protein Phosphatase Activator Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Protein Transport Positive Regulation Of Protein Catabolic Process COPII Vesicle Coating Vesicle Fusion With Golgi Apparatus Negative Regulation Of Autophagosome Assembly Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Protein Glycosylation Heparan Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Phosphoprotein Phosphatase Activity Chondroitin Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Intracellular Protein Transport
Pathways		ER-Phagosome pathway COPII-mediated vesicle transport Cargo concentration in the ER COPI-dependent Golgi-to-ER retrograde traffic	A tetrasaccharide linker sequence is required for GAG synthesis Defective B3GAT3 causes JDSSDHD
Drugs			UDP-alpha-D-glucuronic acid Uridine-5'-Diphosphate
Diseases
GWAS		Iris color (L* coordinate) ( 30895295)	Blood protein levels ( 30072576 29875488) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: B3GAT3 CREB3 LMNA STX1A STX5	2 interacting genes: HNRNPD SEC22B
Entrez ID		9554	26229
HPRD ID		04939	07564
Ensembl ID		ENSG00000265808	ENSG00000149541
Uniprot IDs		O75396	G3V150 O94766 Q5U676
PDB IDs		2NUP 2NUT 3EGD 3EGX	1FGG 1KWS 3CU0
Enriched GO Terms of Interacting Partners?
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