TMEM59 and ATG16L1

Number of citations of the paper that reports this interaction (PubMedID 23376921)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TMEM59	ATG16L1
Description		transmembrane protein 59	autophagy related 16 like 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Cis Cisterna Golgi Trans Cisterna Golgi Membrane Lysosome Lysosomal Membrane Late Endosome Golgi Medial Cisterna Plasma Membrane Integral Component Of Membrane Late Endosome Membrane Extracellular Exosome	Autophagosome Membrane Autophagosome Cytosol Axoneme Phagophore Assembly Site Membrane
	Molecular Function	Endopeptidase Activity Protein Binding	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding GTPase Binding
	Biological Process	Proteolysis Autophagy Positive Regulation Of Autophagy Negative Regulation Of Protein Processing Negative Regulation Of Protein Glycosylation In Golgi Negative Regulation Of Protein Localization To Plasma Membrane	Autophagosome Assembly Protein Transport Macroautophagy Negative Stranded Viral RNA Replication
Pathways			Macroautophagy Macroautophagy
Drugs
Diseases			Crohn's disease
GWAS		Parkinson disease and lewy body pathology ( 25663231)	Bilirubin levels ( 31319653) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17435756 17554300 21102463 23128233) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		2 interacting genes: ATG16L1 ERRFI1	16 interacting genes: APP ATG12 ATG5 C3 CSNK2A1 CSNK2A2 GAN GIGYF2 NOD1 OPTN PLD3 RAB33A RAB33B SCAP TMEM59 UBC
Entrez ID		9528	55054
HPRD ID		12731	16498
Ensembl ID		ENSG00000116209	ENSG00000085978
Uniprot IDs		D3DQ48 Q5T6Z8 Q5T703 Q9BXS4	A0A024R494 A0A024R4B6 Q17RG0 Q53SV2 Q676U5
PDB IDs			4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX
Enriched GO Terms of Interacting Partners?
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