AKAP5 and KCNJ2

Number of citations of the paper that reports this interaction (PubMedID 11287423)
20

Data Source:
HPRD (in vitro, in vivo)

		AKAP5	KCNJ2
Description		A-kinase anchoring protein 5	potassium inwardly rectifying channel subfamily J member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Dendrite Membrane Dendritic Spine Membrane Raft Excitatory Synapse	Cell Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Intercalated Disc T-tubule Intrinsic Component Of Membrane Neuronal Cell Body Dendritic Spine
	Molecular Function	Protein Binding Calmodulin Binding Adenylate Cyclase Binding SH3 Domain Binding Protein Phosphatase 2B Binding Beta-2 Adrenergic Receptor Binding Protein Kinase A Regulatory Subunit Binding Glutamate Receptor Binding GABA Receptor Binding Protein Kinase A Binding Molecular Adaptor Activity Scaffold Protein Binding	Inward Rectifier Potassium Channel Activity Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Protein Targeting Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Regulation Of Protein Kinase A Signaling Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Protein Localization To Plasma Membrane	Potassium Ion Transport Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Magnesium Ion Transport Cellular Potassium Ion Homeostasis Regulation Of Ion Transmembrane Transport Protein Homotetramerization Relaxation Of Cardiac Muscle Regulation Of Resting Membrane Potential Regulation Of Membrane Repolarization Cardiac Conduction Cellular Response To Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Relaxation Of Skeletal Muscle Positive Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Trafficking of AMPA receptors ROBO receptors bind AKAP5 ROBO receptors bind AKAP5	Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Atrial fibrillation Short QT syndrome Andersen-Tawil syndrome (ATS)
GWAS			Adolescent idiopathic scoliosis (severe) ( 24023777) Atrial fibrillation ( 29892015) Birth weight ( 31043758) Chin dimples ( 27182965) Dentures ( 31235808) Depressive episodes in bipolar disorder ( 26297903) Early cardiac repolarization ( 22342860) Formal thought disorder in schizophrenia ( 22648509) Hip circumference adjusted for BMI ( 25673412) Lung function (forced vital capacity) ( 24929828) Macular thickness ( 30535121) Metabolite levels ( 23823483) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Prudent dietary pattern ( 28644415) Pulmonary function (smoking interaction) ( 23284291) QT interval ( 30679814 24952745 19305409) Refractive error ( 23396134) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Thyrotoxic hypokalemic periodic paralysis ( 22863731 22399142) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		14 interacting genes: ADRB2 CALM1 DLG1 DLG4 GABRB1 GABRB3 IQGAP1 KCNJ2 PPP3CA PRKAR2A PRKAR2B PRKCA RET TRPV1	14 interacting genes: AKAP5 CASK DLG1 DLG2 DLG3 DLG4 FLNA IL16 KCNJ11 KCNJ16 KCNJ4 KCNJ8 PATJ TRAK2
Entrez ID		9495	3759
HPRD ID		05255	02815
Ensembl ID		ENSG00000179841	ENSG00000123700
Uniprot IDs		P24588 Q6PG46	P63252
PDB IDs		2H9R 3LL8 5NIN
Enriched GO Terms of Interacting Partners?
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