MED20 and POLR1B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MED20	POLR1B
Description		mediator complex subunit 20	RNA polymerase I subunit B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Mediator Complex	Nucleoplasm Nucleolus RNA Polymerase I Complex Cytosol
	Molecular Function	Transcription Coactivator Activity DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Ubiquitin Protein Ligase Activity	DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Ribonucleoside Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Nucleic Acid-templated Transcription	Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Embryo Implantation RRNA Transcription Nucleologenesis Positive Regulation Of Gene Expression, Epigenetic
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978 27863252) Mean corpuscular volume ( 23263863 20139978 27863252) Metabolite levels ( 23823483) Red blood cell count ( 20139978)
Interacting Genes		7 interacting genes: CD300C ESR1 ESR2 MED18 MED29 MED8 POLR1B	14 interacting genes: AKT2 CCND1 EIF3L ESR1 GIT2 HDAC6 LDB1 LZTR1 MED20 NFKBIB POLR1E RPL37 RRN3 ZNF207
Entrez ID		9477	84172
HPRD ID		15638	06852
Ensembl ID		ENSG00000124641	ENSG00000125630
Uniprot IDs		B3KUJ9 Q9H944	B7Z1W6 Q9H9Y6
PDB IDs
Enriched GO Terms of Interacting Partners?
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