HAND2 and CENPB

Number of citations of the paper that reports this interaction (PubMedID 11812799)
17

Data Source:
HPRD (two hybrid)

		HAND2	CENPB
Description		heart and neural crest derivatives expressed 2	centromere protein B
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Protein-containing Complex	Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nuclear Body Nuclear Pericentric Heterochromatin
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific AT DNA Binding Protein Binding Transcription Factor Binding Activating Transcription Factor Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding E-box Binding	DNA Binding Chromatin Binding Satellite DNA Binding Centromeric DNA Binding Sequence-specific DNA Binding
	Biological Process	Angiogenesis In Utero Embryonic Development Heart Looping Suckling Behavior Cardiac Right Ventricle Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Apoptotic Process Involved In Heart Morphogenesis Noradrenergic Neuron Differentiation Regulation Of Transcription By RNA Polymerase II Heart Development Adult Heart Development Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Developmental Process Regulation Of Tissue Remodeling Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Tongue Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Thymus Development Peripheral Nervous System Neuron Development Cartilage Morphogenesis Coronary Artery Morphogenesis Visceral Serous Pericardium Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of P38MAPK Cascade Primary Palate Development Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis
Pathways		Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416822 30061737 29892015) Chin dimples ( 27182965) Early onset atrial fibrillation ( 28460022) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678)
Interacting Genes		15 interacting genes: CENPB COPS5 DNMT3L EP300 GATA4 HAND1 HEY2 HEYL NPM1 PHOX2A PPP2R5D PRKACA PRKCA TCF3 TCF4	19 interacting genes: ANXA7 APP CDKN1A CENPW CSNK2B FBXO25 GADD45A GFI1B GSK3B HAND2 NR3C1 PARP1 PARP2 PIN1 RPS6KA6 SH2D3A SMN1 TAC1 TK1
Entrez ID		9464	1059
HPRD ID		03872	00314
Ensembl ID		ENSG00000164107	ENSG00000125817
Uniprot IDs		P61296	P07199
PDB IDs			1BW6 1HLV 1UFI
Enriched GO Terms of Interacting Partners?
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