MED27 and AFP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MED27	AFP
Description		mediator complex subunit 27	alpha fetoprotein
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Mediator Complex	Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen
	Molecular Function	Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Activity	Fatty Acid Binding Protein Binding Zinc Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Nucleic Acid-templated Transcription	Ovulation From Ovarian Follicle Transport Progesterone Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process SMAD Protein Signal Transduction
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694)	Blood protein levels ( 30072576) Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)
Interacting Genes		11 interacting genes: AFP ARFGAP1 ESR1 FBXO7 MED19 MED22 MED30 MED8 MED9 RBPJ SOX5	10 interacting genes: AP4S1 CCR5 EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 SGSM2 XIAP
Entrez ID		9442	174
HPRD ID		05438	00074
Ensembl ID		ENSG00000160563	ENSG00000081051
Uniprot IDs		A0A024R8B7 Q6P2C8	P02771
PDB IDs			3MRK
Enriched GO Terms of Interacting Partners?
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