HAND1 and DNMT3L

Number of citations of the paper that reports this interaction (PubMedID 24952347)
9

Data Source:
BioGRID (pull down)

		HAND1	DNMT3L
Description		heart and neural crest derivatives expressed 1	DNA methyltransferase 3 like
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm RNA Polymerase II Transcription Factor Complex	Nucleus Cytosol ESC/E(Z) Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Transcription Coactivator Activity Protein Binding Transcription Factor Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Transcription Regulatory Region DNA Binding	Protein Binding Enzyme Activator Activity Enzyme Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Mesoderm Formation Blastocyst Development Trophectodermal Cell Differentiation Heart Looping Embryonic Heart Tube Formation Cardiac Left Ventricle Formation Cardiac Right Ventricle Formation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Heart Development Developmental Process Embryonic Heart Tube Development Odontogenesis Of Dentin-containing Tooth Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Mesenchyme Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Male Meiosis I Spermatogenesis DNA Methylation On Cytosine DNA Methylation Involved In Gamete Generation Positive Regulation Of Catalytic Activity Negative Regulation Of Transcription, DNA-templated Stem Cell Differentiation Negative Regulation Of DNA Methylation Positive Regulation Of DNA Methylation
Pathways			DNA methylation
Drugs
Diseases
GWAS		Chin dimples ( 27182965) Global electrical heterogeneity phenotypes ( 29622589) Monobrow ( 27182965) QRS complex (Cornell) ( 27659466) QRS duration ( 30679814 27577874 31251759 25035420)
Interacting Genes		15 interacting genes: ACHE DNMT3L FHL2 G3BP1 HAND2 HEY2 HEYL MEF2A MYOD1 PPP2R5D PRKACA PRKCA SRA1 TCF12 TCF3	77 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1
Entrez ID		9421	29947
HPRD ID		03871	09417
Ensembl ID		ENSG00000113196	ENSG00000142182
Uniprot IDs		O96004	Q9UJW3
PDB IDs			2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57
Enriched GO Terms of Interacting Partners?
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