TTYH2 and CCND2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TTYH2	CCND2
Description		tweety family member 2	cyclin D2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Chloride Channel Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Intracellular Calcium Activated Chloride Channel Activity Protein Binding Volume-sensitive Chloride Channel Activity	Protein Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Chloride Transmembrane Transport	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Positive Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Stimuli-sensing channels	Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity
Drugs
Diseases			Testicular cancer
GWAS		Systolic blood pressure (cigarette smoking interaction) ( 26752167)	Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Colorectal cancer ( 30529582 26151821 24836286 23266556 23263487) Colorectal cancer or advanced adenoma ( 30510241) Glucocorticoid-induced osteonecrosis ( 26265699) Height ( 28552196 28270201) Major depressive disorder ( 19107115 23377640) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 28017375) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 27841878 30578418) QT interval (drug interaction) ( 23459443) Red blood cell count ( 20139978 28017375) Red blood cell traits ( 23222517) Smoking behaviour (cigarettes smoked per day) ( 30679032) Type 2 diabetes ( 22885922 30054458 29358691 30297969 31118516 28869590)
Interacting Genes		12 interacting genes: CCND2 CDKN2B ERBB2 FGFR4 GRM1 IGF1R IKBKG KAT2A KDELR2 NEDD4 NF2 PDGFRA	63 interacting genes: ABCB5 ABL1 AKAP8 AKT1 ARAF ARNT AURKA BECN1 CALM1 CALM2 CALM3 CBLC CCNE1 CD44 CDK4 CDK5 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C DMTF1 EPHA2 ERBB2 FBXL2 FGFR4 FZR1 GLIS2 GRM1 H1-1 HGF HIF1A KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MET NF2 NPDC1 PCGF2 PDGFRA PIK3CA PSMD10 PTEN RAF1 RASSF1 RB1 RELA RUNX1 SERTAD1 STK11 TEAD2 TERT TEX11 TNFRSF1A TSC1 TTYH2
Entrez ID		94015	894
HPRD ID		16394	00451
Ensembl ID		ENSG00000141540	ENSG00000118971
Uniprot IDs		B4DKD1 Q8N3U8 Q9BSA4	P30279
PDB IDs			6EI2
Enriched GO Terms of Interacting Partners?
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