TGFBRAP1 and ACVRL1

Number of citations of the paper that reports this interaction (PubMedID 11278302)
14

Data Source:
HPRD (in vivo)

		TGFBRAP1	ACVRL1
Description		transforming growth factor beta receptor associated protein 1	activin A receptor like type 1
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Membrane CORVET Complex Intracellular Membrane-bounded Organelle	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Dendrite Neuronal Cell Body Receptor Complex BMP Receptor Complex
	Molecular Function	Transforming Growth Factor Beta Receptor Binding Protein Binding SMAD Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Protein Kinase Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding BMP Receptor Activity
	Biological Process	Regulation Of Transcription, DNA-templated Intracellular Protein Transport Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Endosome To Lysosome Transport Vesicle-mediated Transport Endosomal Vesicle Fusion	Angiogenesis Response To Hypoxia In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Maturation Blood Vessel Remodeling Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Endocardial Cushion Morphogenesis Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Phosphorylation Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Blood Circulation Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Dorsal Aorta Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Focal Adhesion Assembly Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Endothelial Tube Morphogenesis Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Endocardial Cushion To Mesenchymal Transition Negative Regulation Of DNA Biosynthetic Process
Pathways			Signaling by BMP
Drugs			ATP
Diseases			Hereditary hemorrhagic telangiectasia (HHT)
GWAS		AIDS ( 19754311) Body mass index ( 26426971) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Menarche (age at onset) ( 27182965) Obesity-related traits ( 23251661) Preeclampsia ( 23551011)	Hematocrit ( 29403010) Hemoglobin ( 29403010) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Plateletcrit ( 27863252) Urate levels ( 23263486) White blood cell count ( 27863252)
Interacting Genes		10 interacting genes: ACVR1B ACVR2B ACVRL1 ALOX5 BMPR1A EIF4E2 SMAD2 SMAD4 TGFBR1 TGFBR2	13 interacting genes: ACVR2A BAMBI CSNK2B FKBP1A GDF2 SMAD1 SNX6 TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBRAP1 XIAP
Entrez ID		9392	94
HPRD ID		06948	03181
Ensembl ID		ENSG00000135966	ENSG00000139567
Uniprot IDs		Q8WUH2	A0A0S2Z310 P37023
PDB IDs			2LCR 3MY0 4FAO
Enriched GO Terms of Interacting Partners?
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