MYOCD and MAMSTR

Number of citations of the paper that reports this interaction (PubMedID 16818234)
47

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		MYOCD	MAMSTR
Description		myocardin	MEF2 activating motif and SAP domain containing transcriptional regulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coactivator Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Histone Deacetylase Binding RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Binding R-SMAD Binding	RNA Polymerase II Transcription Factor Binding Transcription Coregulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth By Extracellular Stimulus Vasculogenesis Response To Hypoxia Cardiac Ventricle Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cardiocyte Differentiation Regulation Of Histone Acetylation Vascular Smooth Muscle Cell Differentiation Positive Regulation Of DNA Binding Cellular Component Maintenance Regulation Of Myoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Lung Alveolus Development Digestive Tract Development Positive Regulation Of DNA-binding Transcription Factor Activity Smooth Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Uterus Development Urinary Bladder Development Ductus Arteriosus Closure Negative Regulation Of Amyloid-beta Clearance Regulation Of Phenotypic Switching Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Differentiation	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Myotube Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Metabolite levels ( 23823483) PR interval ( 30679814 30046033) QRS duration ( 31251759) Systolic blood pressure change trajectories ( 27980656) Testosterone levels ( 22675492)	Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 21926972) Blood urea nitrogen levels ( 31152163) Crohn's disease ( 28067908) Dentures ( 31235808) Estimated glomerular filtration rate ( 31152163 31451708) Inflammatory bowel disease ( 28067908) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Multiple sclerosis ( 21833088) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pubertal anthropometrics ( 23449627) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		11 interacting genes: GOPC GSK3B KDM3A MAMSTR MRTFA MYOD1 SMAD2 SMAD3 SMARCA4 SRF STUB1	1 interacting genes: MYOCD
Entrez ID		93649	284358
HPRD ID		09362	08204
Ensembl ID		ENSG00000141052	ENSG00000176909
Uniprot IDs		Q8IZQ8	Q6ZN01
PDB IDs
Enriched GO Terms of Interacting Partners?
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