LGI1 and ADAM22

Number of citations of the paper that reports this interaction (PubMedID 16990550)
109

Data Source:
HPRD (in vitro)

		LGI1	ADAM22
Description		leucine rich glioma inactivated 1	ADAM metallopeptidase domain 22
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Junction Synaptic Cleft Glutamatergic Synapse	Plasma Membrane Integral Component Of Membrane Axon Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding
	Biological Process	Nervous System Development Axon Guidance Positive Regulation Of Cell Growth Neuron Projection Development Positive Regulation Of Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Proteolysis Cell Adhesion Negative Regulation Of Cell Adhesion Central Nervous System Development Adult Locomotory Behavior Myelination In Peripheral Nervous System Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Pathways		LGI-ADAM interactions	LGI-ADAM interactions
Drugs
Diseases		Autosomal dominant temporal lobe epilepsy (ADTLE); Autosomal dominant partial epilepsy with auditory features (ADPEAF)
GWAS		Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Response to perphenazine in schizophrenia ( 29503163)	Blood protein levels ( 30072576) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126)
Interacting Genes		2 interacting genes: ADAM22 SLC27A2	6 interacting genes: APP EPS8 LGI1 RAC2 YWHAB YWHAZ
Entrez ID		9211	53616
HPRD ID		05216	04751
Ensembl ID		ENSG00000108231	ENSG00000008277
Uniprot IDs		A0A0S2Z4S7 A0A0S2Z4X3 A0A0S2Z5G1 A0A1B0GUD3 O95970	Q08AL8 Q9P0K1
PDB IDs		5Y2Z 5Y30 5Y31	3G5C 5Y2Z 5Y31
Enriched GO Terms of Interacting Partners?
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