CD4 and TFRC

Number of citations of the paper that reports this interaction (PubMedID 14705953)
2

Data Source:
HPRD (in vivo)

		CD4	TFRC
Description		CD4 molecule	transferrin receptor
Image
GO Annotations	Cellular Component	Cell Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Vesicle Membrane T Cell Receptor Complex Membrane Raft	Extracellular Region Extracellular Space Cell Endosome Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Melanosome Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle Extracellular Vesicle HFE-transferrin Receptor Complex
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Coreceptor Activity Immunoglobulin Binding Enzyme Binding Protein Kinase Binding Signaling Receptor Activity Interleukin-16 Binding Interleukin-16 Receptor Activity MHC Class II Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Tyrosine Kinase Binding	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Transferrin Receptor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Cytokine Production Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Induction By Virus Of Host Cell-cell Fusion Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Fusion Of Virus Membrane With Host Plasma Membrane Cytokine-mediated Signaling Pathway T Cell Differentiation Macrophage Differentiation Response To Estradiol Maintenance Of Protein Location In Cell Response To Vitamin D Positive Regulation Of Kinase Activity Helper T Cell Enhancement Of Adaptive Immune Response Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Entry Into Host T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Monocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Entry Into Host Cell Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Calcium Ion Transport Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus	Regulation Of Cell Growth Positive Regulation Of Protein Phosphorylation Iron Ion Transport Cellular Iron Ion Homeostasis Positive Regulation Of Gene Expression Osteoclast Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Complex Assembly Receptor Internalization Positive Regulation Of Peptidyl-serine Phosphorylation Transferrin Transport Cellular Response To Drug Positive Regulation Of T Cell Proliferation Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Bone Resorption Positive Regulation Of Isotype Switching Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Membrane Organization Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor
Pathways		Alpha-defensins Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Vpu mediated degradation of CD4 Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Other interleukin signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Transferrin endocytosis and recycling
Drugs		Antithymocyte immunoglobulin (rabbit)	Iron
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Response to Vitamin E supplementation ( 22437554)	Asthma ( 30929738) Asthma (adult onset) ( 30929738) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 25352340) Mean corpuscular hemoglobin ( 28453575 20139978 27863252 19862010) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 28453575 20139978 27863252 19862010) Neurofibrillary tangles ( 31497858) Pancreatic cancer ( 22158540) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		38 interacting genes: ABCB1 ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCHF4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119	12 interacting genes: ACAP1 B4GALT1 CD247 CD4 GABARAP HFE LMNA RAB5B RAB8A RANBP9 SGTA TF
Entrez ID		920	7037
HPRD ID		01740	01812
Ensembl ID		ENSG00000010610	ENSG00000072274
Uniprot IDs		A0A4Y5UGE4 B0AZV7 B4DT49 P01730	A8K6Q8 B7Z2I6 G3V0E5 P02786 Q7Z3E0
PDB IDs		1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1OPN 1OPT 1OPW 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3J70 3JCB 3JCC 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4H8W 4JM2 4P9H 4Q6I 4R2G 4R4H 4RQS 5A7X 5A8H 5CAY 5THR 5U1F 5VN3 6CM3 6EDU 6MEO 6MET	1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N 6D03 6D04 6D05 6GSR 6H5I
Enriched GO Terms of Interacting Partners?
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