OSMR and OSM

Number of citations of the paper that reports this interaction (PubMedID 8999038)
85

Data Source:
HPRD (in vitro, in vivo)

		OSMR	OSM
Description		oncostatin M receptor	oncostatin M
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Oncostatin-M Receptor Complex External Side Of Plasma Membrane Apical Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Receptor Activity Oncostatin-M Receptor Activity Protein Binding Growth Factor Binding Cytokine Binding	Cytokine Activity Oncostatin-M Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway	Positive Regulation Of Acute Inflammatory Response Immune Response Multicellular Organism Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Oncostatin-M-mediated Signaling Pathway Regulation Of Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Interleukin-17 Secretion
Pathways		IL-6-type cytokine receptor ligand interactions	Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Central retinal vein equivalent ( 31597446) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 26192919 28067908) Daytime sleep phenotypes ( 27126917) Inflammatory bowel disease ( 26192919 28067908) Microalbuminuria ( 26631737) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Postoperative survival time in hepatocellular carcinoma ( 30945673 30945699) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Ulcerative colitis ( 26192919 28067908)	Coronary artery disease ( 29212778) Delirium ( 29631748) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Nephropathy ( 21399633) Suicidal ideation ( 30145303) Tonsillectomy ( 27941131)
Interacting Genes		6 interacting genes: GAPDH IL6ST JAK1 JAK2 MTDH OSM	12 interacting genes: APP COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 IL6ST LIFR OSMR TNNT1 ZNF410
Entrez ID		9180	5008
HPRD ID		03446	01300
Ensembl ID		ENSG00000145623	ENSG00000099985
Uniprot IDs		Q99650	B5MCX1 P13725
PDB IDs			1EVS
Enriched GO Terms of Interacting Partners?
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