AP4M1 and USP47

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		AP4M1	USP47
Description		adaptor related protein complex 4 subunit mu 1	ubiquitin specific peptidase 47
Image			No pdb structure
GO Annotations	Cellular Component	Early Endosome Trans-Golgi Network Cytosol AP-4 Adaptor Complex Clathrin Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane Extracellular Exosome	Nucleoplasm Cytoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity WD40-repeat Domain Binding Ubiquitinyl Hydrolase Activity
	Biological Process	Protein Targeting Protein Targeting To Lysosome Intracellular Protein Transport Golgi To Endosome Transport Protein Localization Golgi To Lysosome Transport Protein Localization To Basolateral Plasma Membrane	Base-excision Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Positive Regulation Of Cell Growth Cellular Response To UV Monoubiquitinated Protein Deubiquitination Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Lysosome Vesicle Biogenesis	Ub-specific processing proteases
Drugs
Diseases		Cerebral palsy
GWAS			Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		14 interacting genes: AP4B1 ARF1 CACNG3 CD63 CHTF8 DDX52 GRID2 GRIN2A GRIN2B LAMP2 PMPCB TGOLN2 USP47 ZBTB22	6 interacting genes: AP4M1 MED29 MED9 PLA2G2A SNCA UBC
Entrez ID		9179	55031
HPRD ID		03803	11668
Ensembl ID		ENSG00000221838	ENSG00000170242
Uniprot IDs		C9JC87 O00189	Q68D97 Q96K76
PDB IDs		3L81 4MDR
Enriched GO Terms of Interacting Partners?
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