AIP and PDE4A

Number of citations of the paper that reports this interaction (PubMedID 12810716)
37

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		AIP	PDE4A
Description		aryl hydrocarbon receptor interacting protein	phosphodiesterase 4A
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Aryl Hydrocarbon Receptor Complex	Nucleoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Transcription Factor Binding Aryl Hydrocarbon Receptor Binding GAF Domain Binding Unfolded Protein Binding	3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding CAMP Binding Metal Ion Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Protein Targeting To Mitochondrion Xenobiotic Metabolic Process Regulation Of Protein Kinase A Signaling Protein Maturation By Protein Folding Interleukin-12-mediated Signaling Pathway Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Nucleic Acid-templated Transcription	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Regulation Of Protein Kinase A Signaling Cellular Response To Drug Regulation Of CAMP-mediated Signaling
Pathways		Aryl hydrocarbon receptor signalling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	DARPP-32 events G alpha (s) signalling events
Drugs			Caffeine Theophylline Dyphylline Pentoxifylline Enprofylline Dipyridamole Iloprost Oxtriphylline Roflumilast Piclamilast Crisaborole Ibudilast Apremilast PDE4 Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam Trapidil
Diseases
GWAS		Urate levels ( 31578528)	Blood protein levels ( 28240269) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Multiple sclerosis ( 31604244)
Interacting Genes		16 interacting genes: AHR ARNT CLEC7A CSNK2A1 EGFR GNA13 GNAQ HSP90AA1 IKBKG IRF7 PDE4A PPARA PTGES3 STIP1 TNNI3K TOMM20	3 interacting genes: AIP LYN PIAS4
Entrez ID		9049	5141
HPRD ID		10408	02527
Ensembl ID		ENSG00000110711	ENSG00000065989
Uniprot IDs		G9I2H4 O00170	P27815
PDB IDs		2LKN 4AIF 4APO	2QYK 3I8V 3TVX
Enriched GO Terms of Interacting Partners?
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