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NAT8 and SMAD4
Number of citations of the paper that reports this interaction (PubMedID
15761153
)
246
Data Source:
HPRD
(in vivo)
NAT8
SMAD4
Description
N-acetyltransferase 8 (putative)
SMAD family member 4
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Integral Component Of Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Nuclear Chromatin
Cell
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Centrosome
Cytosol
Activin Responsive Factor Complex
SMAD Protein Complex
Molecular Function
Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
Protein Binding
Cysteine-S-conjugate N-acetyltransferase Activity
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Proximal Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Transcription Coregulator Activity
Protein Binding
Collagen Binding
Transforming Growth Factor Beta Receptor, Common-partner Cytoplasmic Mediator Activity
Identical Protein Binding
Protein Homodimerization Activity
Sulfate Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Metal Ion Binding
I-SMAD Binding
R-SMAD Binding
Molecular Function Regulator
Biological Process
Glutathione Metabolic Process
Positive Regulation Of Gene Expression
Peptidyl-lysine N6-acetylation
Response To Drug
Negative Regulation Of Apoptotic Process
Cellular Protein Metabolic Process
Amyloid-beta Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Ovarian Follicle Development
Branching Involved In Ureteric Bud Morphogenesis
Response To Hypoxia
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Outflow Tract Septum Morphogenesis
Atrioventricular Valve Formation
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Left Ventricular Cardiac Muscle Tissue Morphogenesis
Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Brainstem Development
Cellular Iron Ion Homeostasis
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Spermatogenesis
Single Fertilization
Axon Guidance
Cell Proliferation
Negative Regulation Of Cell Proliferation
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Neural Crest Cell Differentiation
Protein Deubiquitination
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Growth
BMP Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Somite Rostral/caudal Axis Specification
Regulation Of Transforming Growth Factor Beta2 Production
Positive Regulation Of Luteinizing Hormone Secretion
Somatic Stem Cell Population Maintenance
Intracellular Signal Transduction
Atrioventricular Canal Development
Endothelial Cell Activation
Embryonic Digit Morphogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Follicle-stimulating Hormone Secretion
Mesendoderm Development
Developmental Growth
Neuron Fate Commitment
Sebaceous Gland Development
Formation Of Anatomical Boundary
Regulation Of Binding
Positive Regulation Of Histone H3-K4 Methylation
Regulation Of Hair Follicle Development
Uterus Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Negative Regulation Of Cell Death
Endocardial Cell Differentiation
Female Gonad Morphogenesis
Pri-miRNA Transcription By RNA Polymerase II
Secondary Palate Development
Interleukin-6-mediated Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Response To Transforming Growth Factor Beta
Cellular Response To BMP Stimulus
Metanephric Mesenchyme Morphogenesis
Nephrogenic Mesenchyme Morphogenesis
Seminiferous Tubule Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Negative Regulation Of Cardiac Myofibril Assembly
Positive Regulation Of Histone H3-K9 Acetylation
Pathways
Amyloid fiber formation
Signaling by NODAL
Signaling by Activin
Signaling by BMP
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
RUNX2 regulates bone development
RUNX3 regulates CDKN1A transcription
RUNX3 regulates BCL2L11 (BIM) transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
Colorectal cancer
Hereditary hemorrhagic telangiectasia (HHT)
Pancreatic cancer
Juvenile polyposis syndrome
GWAS
Blood metabolite levels (
24816252
)
Blood metabolite ratios (
24816252
)
Chronic kidney disease (
20383146
)
Creatinine levels (
20383145
)
Estimated glomerular filtration rate (
31015462
30604766
)
Glomerular filtration rate (
23535967
)
Glomerular filtration rate (creatinine) (
28452372
)
Metabolic traits (
21886157
)
Metabolite levels (
21931564
)
Metabolite levels (X-11787) (
23934736
)
Serum metabolite concentrations in chronic kidney disease (
29545352
)
Serum metabolite levels (
24625756
23093944
)
Urinary metabolite levels in chronic kidney disease (
29545352
31959995
)
Urinary metabolite modules (eigenmetabolites) in chronic kidney disease (
31959995
)
Urinary metabolite ratios in chronic kidney disease (
29545352
)
Urinary metabolites (
26352407
)
Asthma (
30929738
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Immune response to anthrax vaccine (
22658931
)
Metabolite levels (
23823483
)
Oligoclonal band status in multiple sclerosis (
25616667
)
Interacting Genes
3 interacting genes:
LMNA
SMAD4
TGFBR1
189 interacting genes:
ACVR1B
AKT1
AP2B1
APBB2
AR
ARFRP1
ARL5B
ATF2
ATF7IP
BCAS3
BEX1
BRCA1
BTRC
CAMK2G
CD59
CEBPA
CEBPB
CEBPD
CHEK1
CITED1
CNKSR1
COPS5
CREBBP
CSH1
CSH2
CTCF
CTNNB1
CYFIP2
DACH1
DCP1A
DCP1B
DKK3
DLX1
DNAJB2
DNMT3L
DVL1
ECSIT
EEF1A1
EID2
EIF2AK4
EP300
ERBIN
ESR1
ESR2
EWSR1
FBLN1
FBXO30
FBXO34
FHL2
FHL3
FN1
FOXG1
FOXH1
FOXO1
FOXO3
FOXO4
FSTL3
GATA2
GLI3
GPNMB
GREB1
HDGF
HDLBP
HMG20A
HNF4A
HOXA9
HOXC8
HYAL2
IL24
ITK
JUN
JUNB
JUND
LEF1
LMO4
LRATD2
LYPD3
MAPK1
MAPK13
MAX
MDM4
MECOM
MEF2A
MEX3B
MYOD1
NAT8
NEK6
NELFCD
NFIA
NKX3-2
NOTCH4
NR0B2
NRAS
NUAK2
NUP214
OTUB1
PAK1
PAPPA2
PARD3
PBK
PIAS1
PIAS2
PIAS3
PIAS4
PLG
PLK4
PRKAR1B
PRKAR2A
PRPF40A
PSG2
PSG9
PSMD11
RAB13
RAB25
RAB2B
RAB34
RAB38
RAB3B
RAC2
RALA
RASD2
RASL12
RASSF5
RBL1
RELA
RFX1
RHEBL1
RHOD
RHOG
RHOJ
RIPK2
RMND5B
RPL28
RPS27A
RRAS2
RSPH14
S100A14
SASH3
SERPINA1
SERPINB5
SKI
SKIL
SKP2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD7
SMAD9
SNIP1
SNRNP70
SNW1
SOX12
SP1
SPTBN1
SQSTM1
STK11IP
STK35
STUB1
TCTA
TDG
TENM3
TFE3
TGFBR1
TGFBR2
TGFBRAP1
THRSP
TIAF1
TM9SF2
TOB1
TRAP1
TSSK3
UBA52
UBB
UBE2I
UBE2L3
UBE2Z
UHRF2
USB1
USP4
USP9X
WWOX
XPO5
ZBED5
ZBTB7A
ZMYM2
ZNF423
ZNF521
ZNF8
Entrez ID
9027
4089
HPRD ID
08413
02995
Ensembl ID
ENSG00000144035
ENSG00000141646
Uniprot IDs
Q9UHE5
A0A024R274
Q13485
PDB IDs
1DD1
1G88
1MR1
1U7F
1U7V
1YGS
5C4V
5MEY
5MEZ
5MF0
5UWU
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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