TRIM15 and FERMT3

Number of citations of the paper that reports this interaction (PubMedID 25450970)
15

Data Source:
BioGRID (protein complementation assay)

		TRIM15	FERMT3
Description		tripartite motif containing 15	fermitin family member 3
Image		No pdb structure
GO Annotations	Cellular Component		Podosome Extracellular Region Membrane Cell Junction Platelet Alpha Granule Lumen Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding	Integrin Binding
	Biological Process	Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Viral Release From Host Cell	Platelet Degranulation Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Integrin Activation Regulation Of Cell-cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Platelet Aggregation
Pathways			Platelet degranulation
Drugs
Diseases			Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Neurociticism ( 29500382) Neuroticism ( 29255261)	Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401)
Interacting Genes		36 interacting genes: ACD ACTB AXIN1 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2U VASP VCL VIM	9 interacting genes: APP EXOSC10 ILK ITGB1 LIMS1 LSM8 PARVA TINF2 TRIM15
Entrez ID		89870	83706
HPRD ID		15551	07440
Ensembl ID		ENSG00000204610	ENSG00000149781
Uniprot IDs		Q5SRL0 Q9C019	Q86UX7
PDB IDs			2YS3
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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