KSR1 and PJA2

Number of citations of the paper that reports this interaction (PubMedID 27195677)
4

Data Source:
BioGRID (enzymatic study)

		KSR1	PJA2
Description		kinase suppressor of ras 1	praja ring finger ubiquitin ligase 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Ruffle Membrane Protein-containing Complex	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Cell Junction Intermediate Filament Cytoskeleton
	Molecular Function	Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Protein C-terminus Binding Mitogen-activated Protein Kinase Kinase Binding Metal Ion Binding Chaperone Binding Hsp90 Protein Binding 14-3-3 Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MAPK Cascade Activation Of MAPKKK Activity Ras Protein Signal Transduction CAMP-mediated Signaling Regulation Of Cell Proliferation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade	Inflammatory Response Long-term Memory Regulation Of Protein Kinase A Signaling Protein Ubiquitination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Hippo Signaling Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of P38MAPK Cascade
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Systemic lupus erythematosus ( 28714469)	Body mass index ( 29273807) Frontotemporal dementia with GRN mutation ( 29724592) Heel bone mineral density ( 30598549)
Interacting Genes		10 interacting genes: BRAP EPHB2 MAP2K1 MAPK1 MARK3 NME1 PJA2 RAF1 UBE2L3 YWHAZ	14 interacting genes: KSR1 MAGED1 MFHAS1 MOB1A PRKAR1A PRKAR2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J1 UBE2L6 UBE2N UBE2W
Entrez ID		8844	9867
HPRD ID		18980	11436
Ensembl ID		ENSG00000141068	ENSG00000198961
Uniprot IDs		Q8IVT5	O43164
PDB IDs		5VYK
Enriched GO Terms of Interacting Partners?
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