PROM1 and PLEKHA5

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		PROM1	PLEKHA5
Description		prominin 1	pleckstrin homology domain containing A5
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cilium Cell Surface Apical Plasma Membrane Microvillus Membrane Vesicle Photoreceptor Outer Segment Membrane Extracellular Exosome Prominosome	Nucleoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Cholesterol Binding Actinin Binding Cadherin Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Retina Layer Formation Photoreceptor Cell Maintenance Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Glomerular Visceral Epithelial Cell Differentiation Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation	Biological_process Reproductive System Development
Pathways			Synthesis of PIPs at the plasma membrane
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Stargardt disease (STGD); Fundus flavimaculatus Retinitis pigmentosa (RP)
GWAS		Dental caries ( 23064961) Glomerular filtration rate in chronic kidney disease ( 26420894) Intracranial aneurysm ( 29531279) Pulse pressure ( 30224653) Self-rated health ( 20707712) Suicide attempts in depression or bipolar disorder ( 24964207)	Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Thalamus volume ( 31530798)
Interacting Genes		4 interacting genes: HDAC6 PIK3R1 PLEKHA5 SRC	36 interacting genes: ADK ARHGEF9 BET1 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 H2AJ KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 RECQL SH3BP5L SOGA1 SPIRE1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG
Entrez ID		8842	54477
HPRD ID		05079	09684
Ensembl ID		ENSG00000007062	ENSG00000052126
Uniprot IDs		A0A0A0N0M1 O43490	A0A024RAY7 Q9HAU0
PDB IDs			2DKP
Enriched GO Terms of Interacting Partners?
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