LIN7A and SLC6A12

Number of citations of the paper that reports this interaction (PubMedID 10228153)
25

Data Source:
HPRD (in vivo, in vitro)

		LIN7A	SLC6A12
Description		lin-7 homolog A, crumbs cell polarity complex component	solute carrier family 6 member 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse Extracellular Exosome MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection
	Molecular Function	Protein Binding L27 Domain Binding	Gamma-aminobutyric Acid:sodium Symporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity Neurotransmitter Binding
	Biological Process	Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Synaptic Vesicle Transport Inner Ear Development Protein-containing Complex Assembly Protein Localization To Basolateral Plasma Membrane	Amino Acid Transmembrane Transport Transport Amino Acid Transport Gamma-aminobutyric Acid Transport
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Amino acid transport across the plasma membrane Na+/Cl- dependent neurotransmitter transporters Creatine metabolism Reuptake of GABA
Drugs			Guvacine
Diseases
GWAS		Age-related cataracts (age at onset) ( 25352737) Dental caries ( 23259602)	Blood metabolite levels ( 24816252) Chronic kidney disease ( 20383146) Diisocyanate-induced asthma ( 25918132) Metabolite levels ( 23823483 23378610)
Interacting Genes		19 interacting genes: ABCA1 ADGRB1 APP BAIAP2 CASK DLG2 DLG3 DLG4 DNAJC5 FAM9B GOLGA2 GRIN2B KCNJ12 MPP3 MPP5 MPP6 NOTCH2NLA SLC6A12 ZYX	3 interacting genes: ERBIN LIN7A REL
Entrez ID		8825	6539
HPRD ID		04542	04358
Ensembl ID		ENSG00000111052	ENSG00000111181
Uniprot IDs		O14910	P48065
PDB IDs
Enriched GO Terms of Interacting Partners?
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