ADAM9 and HTRA4

		ADAM9	HTRA4
Description		ADAM metallopeptidase domain 9	HtrA serine peptidase 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Focal Adhesion Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Intrinsic Component Of External Side Of Plasma Membrane Extracellular Exosome	Extracellular Region
	Molecular Function	Metalloendopeptidase Activity Protein Kinase C Binding Integrin Binding Protein Binding Collagen Binding Metallopeptidase Activity SH3 Domain Binding Laminin Binding Metal Ion Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Insulin-like Growth Factor Binding
	Biological Process	Activation Of MAPKK Activity Membrane Protein Ectodomain Proteolysis Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Manganese Ion Cell Migration Keratinocyte Differentiation Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Macrophage Fusion Response To Tumor Necrosis Factor Response To Laminar Fluid Shear Stress Monocyte Activation Response To Hydrogen Peroxide Positive Regulation Of Protein Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis PMA-inducible Membrane Protein Ectodomain Proteolysis Response To Glucocorticoid Positive Regulation Of Keratinocyte Migration Response To Calcium Ion Cellular Response To Lipopolysaccharide Response To Antineoplastic Agent	Proteolysis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Pathways		Collagen degradation
Drugs		INCB7839
Diseases		Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS
Interacting Genes		13 interacting genes: ADAM32 HTRA4 ITGA3 ITGA6 ITGAV MAD2L2 PLEKHA7 PRKCD SCN8A SH3D19 SH3GLB1 SNX9 TNF	2 interacting genes: ADAM9 GTF2IRD1
Entrez ID		8754	203100
HPRD ID		04091	08818
Ensembl ID		ENSG00000168615	ENSG00000169495
Uniprot IDs		Q13443	P83105
PDB IDs		1M1V
Enriched GO Terms of Interacting Partners?
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