DGAT1 and GABRA4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		DGAT1	GABRA4
Description		diacylglycerol O-acyltransferase 1	gamma-aminobutyric acid type A receptor subunit alpha4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Specific Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite Membrane Chloride Channel Complex Neuron Projection Synapse Postsynapse GABA-ergic Synapse Integral Component Of Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	2-acylglycerol O-acyltransferase Activity Diacylglycerol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity, Transferring Acyl Groups Retinol O-fatty-acyltransferase Activity	GABA-A Receptor Activity Inhibitory Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Triglyceride Metabolic Process Triglyceride Biosynthetic Process Lipid Storage Very-low-density Lipoprotein Particle Assembly Long-chain Fatty-acyl-CoA Metabolic Process Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Neutrophil Degranulation Diacylglycerol Metabolic Process Fatty Acid Homeostasis	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Central Nervous System Development Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport Regulation Of Response To Drug
Pathways		Acyl chain remodeling of DAG and TAG Neutrophil degranulation Triglyceride biosynthesis	GABA receptor activation GABA receptor activation
Drugs			Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Butalbital Topiramate Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Olanzapine Clobazam Meprobamate Meprobamate Eszopiclone Alprazolam Secobarbital Metharbital Metharbital Chlordiazepoxide Amoxapine Thiopental Clorazepate Acamprosate Midazolam Flurazepam Isoflurane Primidone Primidone Halazepam Propofol Diazepam Oxazepam Oxazepam Methylphenobarbital Triazolam Triazolam Ethanol Methoxyflurane Ergoloid mesylate Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Glutethimide Barbital Barbituric acid derivative Flunitrazepam Bromazepam Prazepam Quazepam Nitrazepam Prasterone Taurine Ganaxolone Adipiplon Stiripentol Thiocolchicoside
Diseases
GWAS		Dupuytren's disease ( 28886342)	Cognitive decline (age-related) ( 28078323) Polycystic ovary syndrome ( 30343302) Type 2 diabetes ( 23937595)
Interacting Genes		3 interacting genes: CD1A GABRA4 GPAA1	3 interacting genes: APP DGAT1 PRKCG
Entrez ID		8694	2557
HPRD ID		05360	08839
Ensembl ID		ENSG00000185000	ENSG00000109158
Uniprot IDs		O75907	P48169 X5D7F5
PDB IDs
Enriched GO Terms of Interacting Partners?
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