CHRD and HRG

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CHRD	HRG
Description		chordin	histidine rich glycoprotein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Extracellular Region Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Endolysosome Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding Heparin Binding Cytokine Binding Syndecan Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding Immunoglobulin Binding Heme Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Gastrulation With Mouth Forming Second Mesoderm Formation Positive Regulation Of Mesenchymal Cell Proliferation BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Forebrain Development Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion	Angiogenesis Platelet Degranulation Positive Regulation Of Immune Response To Tumor Cell Chemotaxis Negative Regulation Of Cell Adhesion Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Regulation Of Platelet Activation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endopeptidase Activity Heme Transport Negative Regulation Of Angiogenesis Platelet Activation Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Cell Adhesion Mediated By Integrin Fibrinolysis Positive Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Fungus Cytolysis By Host Of Symbiont Cells Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Fibrinolysis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Endothelial Cell Chemotaxis
Pathways			Platelet degranulation Dissolution of Fibrin Clot
Drugs
Diseases			Inherited thrombophilia
GWAS		Diisocyanate-induced asthma ( 25918132) Platelet count ( 20139978) Plateletcrit ( 27863252)	Activated partial thromboplastin time ( 22703881 20303064) Blood protein levels ( 30072576 29875488 28240269) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		26 interacting genes: ATN1 BMP1 BMP2 CATSPER1 CD36 F2R HOXA1 HRG KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 MEOX2 NOTCH2NLA NR0B2 OTX1 PLSCR1 SMAD3 SPRY2 TLL1 TWSG1	13 interacting genes: C1QA C1QB CHRD FCGR1A FGA FN1 PLG PLSCR1 RABAC1 RCHY1 SPRY1 THBS1 TNFRSF1A
Entrez ID		8646	3273
HPRD ID		04592	00812
Ensembl ID		ENSG00000090539	ENSG00000113905
Uniprot IDs		E7ESX1 Q8N2W7 Q9H2X0	P04196
PDB IDs
Enriched GO Terms of Interacting Partners?
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