RNASET2 and CEP43

		RNASET2	CEP43
Description		ribonuclease T2	centrosomal protein 43
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Nucleus Centrosome Centriole Cytosol Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Endoribonuclease Activity Ribonuclease Activity Lyase Activity Ribonuclease T2 Activity	Protein Binding Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Protein Homodimerization Activity
	Biological Process	RNA Catabolic Process Neutrophil Degranulation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Microtubule Anchoring Negative Regulation Of Protein Tyrosine Kinase Activity Ciliary Basal Body-plasma Membrane Docking
Pathways		Neutrophil degranulation	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Signaling by FGFR1 in disease AURKA Activation by TPX2
Drugs
Diseases		Cystic leukoencephalopathy without megalencephaly
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Crohn's disease ( 28067908 23850713) Endometrial cancer ( 24096698) Graves' disease ( 21841780) Huntington's disease progression ( 28642124) Inflammatory bowel disease ( 28067908 23128233) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Smooth-surface caries ( 24556642) Spontaneous preterm birth (preterm birth) ( 25599974) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Vitiligo ( 20526339 27723757)
Interacting Genes		1 interacting genes: CEP43	8 interacting genes: LINC01558 NAGK PPP2R1B RNASET2 S100A6 TBP TCP10L3 VASP
Entrez ID		8635	11116
HPRD ID		10197	10392
Ensembl ID		ENSG00000026297	ENSG00000213066
Uniprot IDs		D6REQ6 O00584	A0A087WV25 B4DH64 O95684
PDB IDs		3T0O	2D68
Enriched GO Terms of Interacting Partners?
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