UNC5C and NTN1

Number of citations of the paper that reports this interaction (PubMedID 12810718)
40

Data Source:
HPRD (in vitro)

		UNC5C	NTN1
Description		unc-5 netrin receptor C	netrin 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane Lamellipodium Cell Junction Filopodium Dendrite Growth Cone Neuronal Cell Body Synapse	Extracellular Region Basement Membrane Cytoplasm
	Molecular Function	Netrin Receptor Activity Netrin Receptor Activity Involved In Chemorepulsion Protein Binding Tubulin Binding Protein Kinase Binding	Protein Binding
	Biological Process	Apoptotic Process Axon Guidance Brain Development Regulation Of Cell Migration Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Positive Regulation Of Apoptotic Process Chemorepulsion Of Axon Dorsal Root Ganglion Development	Neuron Migration Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Ras Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Proliferation Animal Organ Morphogenesis Tissue Development Dendrite Development Regulation Of Cell Migration Negative Regulation Of Axon Extension Cdc42 Protein Signal Transduction Anterior/posterior Axon Guidance Inner Ear Morphogenesis Positive Regulation Of Axon Extension Regulation Of Synapse Assembly Mammary Gland Duct Morphogenesis Chemorepulsion Of Axon Cell-cell Adhesion Negative Regulation Of Netrin-activated Signaling Pathway Positive Regulation Of Cell Motility
Pathways		Netrin mediated repulsion signals	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases
GWAS		Alcohol dependence symptom count ( 29460428) Blood protein levels ( 30072576 29875488) Cerebrospinal P-tau181p levels ( 20932310) Coronary artery disease ( 29212778) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Major depressive disorder ( 29317602) Obesity-related traits ( 23251661) Obsessive-compulsive symptoms ( 26859814) Optic nerve measurement (cup-to-disc ratio) ( 20395239) Residual cognition ( 28441426) Type 2 diabetes ( 31049640)	Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488) Breast cancer (prognosis) ( 23319801) Cleft lip with or without cleft palate ( 28054174) Cortex volume ( 31530798) Feeling hurt ( 29500382) Heel bone mineral density ( 30598549 28869591) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Orofacial clefts ( 28054174) Percentage gas trapping ( 26030696) Rostral middle frontal gyrus volume ( 31530798) Total grey matter volume ( 31530798)
Interacting Genes		2 interacting genes: DAPK1 NTN1	5 interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C
Entrez ID		8633	9423
HPRD ID		04678	03368
Ensembl ID		ENSG00000182168	ENSG00000065320
Uniprot IDs		A8K385 O95185	O95631
PDB IDs			4URT 6FKQ
Enriched GO Terms of Interacting Partners?
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