NPFF and NPY

Number of citations of the paper that reports this interaction (PubMedID 11325787)
13

Data Source:
HPRD (in vivo)

		NPFF	NPY
Description		neuropeptide FF-amide peptide precursor	neuropeptide Y
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Dendrite Vesicle Perikaryon Axon Terminus Postsynapse	Extracellular Region Extracellular Space Cell Golgi Apparatus Synapse Neuronal Dense Core Vesicle
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Neuropeptide Hormone Activity	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Calcium Channel Regulator Activity
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of Heart Rate Spinal Cord Development Vasopressin Secretion Negative Regulation Of Appetite Response To Morphine Positive Regulation Of Blood Pressure Negative Regulation Of Insulin Secretion Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Maternal Process Involved In Female Pregnancy Somatostatin Secretion	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Blood Pressure Adult Feeding Behavior Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Positive Regulation Of Appetite Intestinal Epithelial Cell Differentiation
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Alpha-Aminoisobutyric Acid L-Tyrosinamide
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Aggressive periodontitis (sex interaction) ( 25256105) Chronotype ( 30696823) Morning person ( 30696823) Periodontitis ( 23459936) Vitamin D levels ( 25208829)
Interacting Genes		4 interacting genes: NPFFR1 NPFFR2 NPY ZDHHC17	15 interacting genes: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1
Entrez ID		8620	4852
HPRD ID		06869	01214
Ensembl ID		ENSG00000139574	ENSG00000122585
Uniprot IDs		O15130	A4D158 P01303
PDB IDs			1QFA 1RON
Enriched GO Terms of Interacting Partners?
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