LY6D and ABCB11

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		LY6D	ABCB11
Description		lymphocyte antigen 6 family member D	ATP binding cassette subfamily B member 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Apical Part Of Cell Intercellular Canaliculus Extracellular Exosome
	Molecular Function		Transporter Activity ATP Binding Sodium-exporting ATPase Activity, Phosphorylative Mechanism Canalicular Bile Acid Transmembrane Transporter Activity Bile Acid-exporting ATPase Activity ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Cell Adhesion Lymphocyte Differentiation Response To Stilbenoid	Bile Acid Biosynthetic Process Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Sodium Ion Transmembrane Transport Transmembrane Transport
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Recycling of bile acids and salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2
Drugs			ATP Clofazimine Glyburide
Diseases			Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS			Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010) Cholesterol, total ( 24097068) Egg allergy ( 25710614) Fasting blood glucose ( 29621232) Fasting plasma glucose ( 18521185) Gamma glutamyl transferase levels ( 29403010) Glycated hemoglobin levels ( 24647736 20858683 31213470 29170429) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 30275531) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolite levels ( 21909109) Systolic blood pressure in sickle cell anemia ( 24058526) Total cholesterol levels ( 28334899 30275531)
Interacting Genes		3 interacting genes: ABCB11 ARFIP2 PKIB	3 interacting genes: HAX1 LY6D NR4A1
Entrez ID		8581	8647
HPRD ID		09370	04436
Ensembl ID		ENSG00000167656	ENSG00000073734
Uniprot IDs		Q14210	O95342
PDB IDs
Enriched GO Terms of Interacting Partners?
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