THOC5 and LIG4

Number of citations of the paper that reports this interaction (PubMedID 22990118)
46

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		THOC5	LIG4
Description		THO complex 5	DNA ligase 4
Image		No pdb structure
GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm	Nuclear Chromosome, Telomeric Region Condensed Chromosome Nucleus Nucleoplasm DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Cytoplasmic Ribonucleoprotein Granule Nonhomologous End Joining Complex
	Molecular Function	MRNA Binding Protein Binding	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Protein C-terminus Binding Ligase Activity Metal Ion Binding
	Biological Process	RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing Monocyte Differentiation MRNA 3'-end Processing Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Primitive Hemopoiesis Negative Regulation Of DNA Damage Checkpoint	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Replication DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Central Nervous System Development Cell Proliferation Response To X-ray Response To Gamma Radiation T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Recombination DNA Ligation Involved In DNA Repair Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion Cellular Response To Ionizing Radiation DNA Biosynthetic Process Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Chromosome Organization
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	2-LTR circle formation Nonhomologous End-Joining (NHEJ)
Drugs
Diseases			DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Carotid atherosclerosis in HIV infection ( 20009918) Lipid traits ( 24023261)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Irritable bowel syndrome ( 29626450)
Interacting Genes		10 interacting genes: CSF1R CSNK2A1 HSPB1 LIG4 LSM3 NXF1 PPIL1 PRKCA THOC7 ZNF830	103 interacting genes: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATP6V0D1 ATR B9D1 BBOF1 CAP1 CLU COL1A2 COMMD1 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FAM214A FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C MT-CO1 MT-CO2 MT-CO3 MT-ND1 MT-ND4 MT-ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS1 WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT
Entrez ID		8563	3981
HPRD ID		16650	03500
Ensembl ID		ENSG00000100296	ENSG00000174405
Uniprot IDs		A0A024R1D6 Q13769	A0A024RE06 A0A0C4DGV9 A8K8Q4 P49917
PDB IDs			1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP 6BKF 6BKG
Enriched GO Terms of Interacting Partners?
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