KRTAP2-4 and ADAMTSL3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KRTAP2-4	ADAMTSL3
Description		keratin associated protein 2-4	ADAMTS like 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Extracellular Region Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Protein Binding Peptidase Activity
	Biological Process	Keratinization	Proteolysis
Pathways		Keratinization Keratinization	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 28724990) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic obstructive pulmonary disease ( 30804561) Height ( 21998595 28552196 20881960 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 25673412) Lean body mass ( 28724990) Optic disc size ( 31809533) Pulse pressure ( 30224653) Schizophrenia ( 28991256 25056061 29483656 30285260) Spine bone size ( 31053729) Waist circumference ( 26785701) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 26785701 25673412 28448500)
Interacting Genes		11 interacting genes: ADAMTSL3 CBX2 CNNM3 KRTAP10-1 KRTAP10-5 PTPMT1 RPS28 SDC3 SHFL TMEM190 ZNF587	6 interacting genes: KRT40 KRTAP10-3 KRTAP10-8 KRTAP2-4 MDFI NOTCH2NLA
Entrez ID		85294	57188
HPRD ID		13936	12426
Ensembl ID		ENSG00000213417	ENSG00000156218
Uniprot IDs		P0C7H8 Q9BYR9	P82987
PDB IDs
Enriched GO Terms of Interacting Partners?
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