FRMD5 and CEP250

		FRMD5	CEP250
Description		FERM domain containing 5	centrosomal protein 250
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Adherens Junction Integral Component Of Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Centrosome Centriole Microtubule Organizing Center Cytosol Protein-containing Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Integrin Binding Protein Binding Cytoskeletal Protein Binding Protein Kinase Binding	Protein Binding Protein C-terminus Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	Regulation Of Cell Migration Actomyosin Structure Organization Positive Regulation Of Cell Adhesion Negative Regulation Of Cell Motility	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Protein Localization To Organelle Detection Of Light Stimulus Involved In Visual Perception Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Centrosome Non-motile Cilium Assembly
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Serum albumin level ( 23022100) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943 20686565) Urinary tract infection frequency ( 28928442) Uterine fibroid number (single vs multiple) ( 30196971)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Height ( 25429064 18391951) Ulcerative colitis ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		2 interacting genes: CEP250 NELFCD	14 interacting genes: APP ATF7IP FAM83D FRMD5 ITCH KAT2B KCNG3 MYL9 NEK2 PDIA6 PHF20 PLEKHA5 TTI1 YWHAG
Entrez ID		84978	11190
HPRD ID		17493	09877
Ensembl ID		ENSG00000171877	ENSG00000126001
Uniprot IDs		A0A087WVP2 B3KVN9 B5MC67 H0YKW6 Q7Z6J6	Q9BV73
PDB IDs
Enriched GO Terms of Interacting Partners?
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