TXNDC17 and TXNRD1

Number of citations of the paper that reports this interaction (PubMedID 14607844)
25

Data Source:
HPRD (in vitro)

		TXNDC17	TXNRD1
Description		thioredoxin domain containing 17	thioredoxin reductase 1
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Fibrillar Center Cell Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Peroxidase Activity Protein Binding Protein-disulfide Reductase Activity	Thioredoxin-disulfide Reductase Activity Protein Binding Electron Transfer Activity Protein Disulfide Oxidoreductase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Tumor Necrosis Factor-mediated Signaling Pathway Oxidation-reduction Process Cellular Oxidant Detoxification	Mesoderm Formation Selenium Compound Metabolic Process Signal Transduction Cell Proliferation Nucleobase-containing Small Molecule Interconversion Regulation Of Lipid Metabolic Process Electron Transport Chain Cellular Response To Oxidative Stress Cell Redox Homeostasis Cellular Oxidant Detoxification
Pathways			PPARA activates gene expression Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates Metabolism of ingested MeSeO2H into MeSeH Uptake and function of diphtheria toxin TP53 Regulates Metabolic Genes
Drugs			Arsenic trioxide Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate Flavin adenine dinucleotide Spermidine Fotemustine motexafin gadolinium PX-12
Diseases
GWAS		LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Logical memory (delayed recall) in normal cognition ( 29274321) Toenail selenium levels ( 25343990)
Interacting Genes		9 interacting genes: AVP DYNLL1 EXOSC8 INS OXT PIGS RUFY1 TINF2 TXNRD1	10 interacting genes: DMRTC2 ESR1 ESR2 GLRX2 POU2F1 POU2F2 PPP1R16A THRA TXNDC17 TXNIP
Entrez ID		84817	7296
HPRD ID		11656	03068
Ensembl ID		ENSG00000129235	ENSG00000198431
Uniprot IDs		A0A140VJY7 Q9BRA2	B7Z2S5 Q16881
PDB IDs		1WOU	1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB
Enriched GO Terms of Interacting Partners?
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