RAE1 and FZD8

		RAE1	FZD8
Description		ribonucleic acid export 1	frizzled class receptor 8
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Cytoplasm Host Cell Mitotic Spindle Pole	Golgi Apparatus Plasma Membrane Integral Component Of Membrane Wnt-Frizzled-LRP5/6 Complex
	Molecular Function	RNA Binding Protein Binding Microtubule Binding Ubiquitin Binding	G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Cell Cycle Viral Process Protein Sumoylation Viral Transcription Cell Division Regulation Of Mitotic Spindle Organization Regulation Of Gene Silencing By MiRNA Cellular Response To Organic Cyclic Compound Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	Angiogenesis G Protein-coupled Receptor Signaling Pathway Neuron Differentiation T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Canonical Wnt Signaling Pathway
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events	Class B/2 (Secretin family receptors) Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
Drugs
Diseases
GWAS			Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)
Interacting Genes		15 interacting genes: AQP7 BUB1 CASS4 CREBRF DDX24 FZD8 HPCA KLRC4 KLRK1 NUMA1 NUP98 NXF1 PCK1 RBM38 RTEL1	7 interacting genes: CUL2 GOPC LRP5 LRP6 RAE1 RYK WNT1
Entrez ID		8480	8325
HPRD ID		11939	05852
Ensembl ID		ENSG00000101146	ENSG00000177283
Uniprot IDs		P78406	Q9H461
PDB IDs		3MMY 4OWR	5UN5 5UN6 6NDZ
Enriched GO Terms of Interacting Partners?
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