CDC42BPA and LIMK1

Number of citations of the paper that reports this interaction (PubMedID 10559936)
329

Data Source:
HPRD (in vitro, in vivo)

		CDC42BPA	LIMK1
Description		CDC42 binding protein kinase alpha	LIM domain kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Cell-cell Junction Lamellipodium Cell Leading Edge Actomyosin Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Nuclear Speck Lamellipodium Neuron Projection
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Heat Shock Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Cell Migration Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Intracellular Signal Transduction	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Axon Extension Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs
Drugs			Dabrafenib
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 31152163) Diastolic blood pressure ( 28135244) Macular thickness ( 30535121) Mercury levels ( 26025379) Myeloid white cell count ( 27863252) Optic cup area ( 25631615 31798171) Optic disc area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Pulse pressure ( 30224653) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		7 interacting genes: CDC42 LIMK1 LIMK2 MYL2 MYL9 PPM1A PPP1R12C	29 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 FBXO7 H1-1 LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SELENOS SRPK1 SSH3 YWHAZ
Entrez ID		8476	3984
HPRD ID		04562	03210
Ensembl ID		ENSG00000143776	ENSG00000106683
Uniprot IDs		Q5VT25	P53667
PDB IDs			3S95 5HVJ 5HVK 5L6W 5NXC
Enriched GO Terms of Interacting Partners?
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