PPP1R9B and ADRA1A

Number of citations of the paper that reports this interaction (PubMedID 11154706)
39

Data Source:
HPRD (in vivo, in vitro)

		PPP1R9B	ADRA1A
Description		protein phosphatase 1 regulatory subunit 9B	adrenoceptor alpha 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleoplasm Cytoplasm Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Lamellipodium Filopodium Dendrite Growth Cone Cortical Actin Cytoskeleton Ruffle Membrane Neuronal Cell Body Dendritic Spine Neck Dendritic Spine Head Cytoplasmic Side Of Dendritic Spine Plasma Membrane	Cell Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Z Disc T-tubule Nuclear Membrane Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Protein Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding Protein C-terminus Binding Protein Phosphatase 1 Binding Kinase Binding D2 Dopamine Receptor Binding Ion Channel Binding Actin Filament Binding	Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Protein Phosphorylation Response To Amphetamine Developmental Process Involved In Reproduction Protein Phosphorylation Actin Filament Organization Cell Cycle Arrest Regulation Of Exit From Mitosis Aging Learning RNA Splicing Dendrite Development Cell Migration Calcium-mediated Signaling Hippocampus Development Cerebral Cortex Development Actin Filament Depolymerization Negative Regulation Of Cell Growth Neuron Projection Development Negative Regulation Of Phosphoprotein Phosphatase Activity Response To Prostaglandin E Response To Nicotine Response To Immobilization Stress Regulation Of Cell Proliferation Filopodium Assembly Response To Steroid Hormone Modulation Of Chemical Synaptic Transmission Male Mating Behavior Reproductive System Development Cellular Response To Morphine Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Response To Clozapine Cellular Response To Peptide Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Actin Cytoskeleton Positive Regulation Of Protein Localization To Actin Cortical Patch Response To Kainic Acid Response To L-phenylalanine Derivative Protein Localization To Cell Periphery Regulation Of Opioid Receptor Signaling Pathway	Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Systemic Arterial Blood Pressure Apoptotic Process Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Adult Heart Development Aging Behavior Negative Regulation Of Cell Proliferation Response To Hormone Negative Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of Action Potential Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Micturition Calcium Ion Transport Into Cytosol Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Pilomotor Reflex Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis
Pathways			Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events
Drugs			Amphetamine Midodrine Citalopram Ziprasidone Cabergoline Dapiprazole Amitriptyline Olanzapine Alfuzosin Clozapine Norepinephrine Mirtazapine Mirtazapine Phenylephrine Loxapine Promazine Dipivefrin Droperidol Prazosin Imipramine Chlorpromazine Chlorpromazine Nortriptyline Amoxapine Amoxapine Clonidine Doxazosin Labetalol Metaraminol Nicardipine Trazodone Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Nicergoline Tamsulosin Methoxamine Trimipramine Risperidone Epinastine Propiomazine Tolazoline Fenoldopam Trifluoperazine Pseudoephedrine Benzphetamine Flupentixol Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Ergoloid mesylate Promethazine Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Ergonovine Paliperidone Bevantolol Ephedrine Mephentermine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Phendimetrazine Acepromazine Thioproperazine Zuclopenthixol Dronedarone Iloperidone R450 Epicept NP-1 Sertindole Mianserin Silodosin Asenapine Droxidopa Xylometazoline Isometheptene Naphazoline Tetryzoline Perospirone Indoramin Dosulepin Etoperidone Cirazoline Synephrine Niguldipine Tiapride
Diseases
GWAS		Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Blood metabolite levels ( 24816252) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Response to amphetamines ( 22952603) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		23 interacting genes: ACTA1 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C CCKAR CCKBR CDKN2A CHRM3 DCX DRD2 MAPK1 PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9A PRKACA RGS2 RPS6KB1 TGOLN2 TIAM1	10 interacting genes: ABR ADRA1B ADRA1D BMP1 CXCR1 CXCR2 FLNC NOS1 PPP1R9B RGS2
Entrez ID		84687	148
HPRD ID		04506	00081
Ensembl ID		ENSG00000108819	ENSG00000120907
Uniprot IDs		Q96SB3	B0ZBD3 P35348
PDB IDs
Enriched GO Terms of Interacting Partners?
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