CUL1 and CDCA3

Number of citations of the paper that reports this interaction (PubMedID 12679038)
48

Data Source:
HPRD (in vitro, in vivo)

		CUL1	CDCA3
Description		cullin 1	cell division cycle associated 3
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Cytosol Adherens Junction
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Iron Ion Homeostasis Cell Proliferation Animal Organ Morphogenesis SCF Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition	Cell Cycle Biological_process Protein Ubiquitination Cell Division
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK - noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Metabolite levels ( 23823483) Uterine fibroid size (maximum volume) ( 30196971)
Interacting Genes		57 interacting genes: BTRC CAND1 CDC34 CDCA3 CDK9 CDKN1B CENPE CENPW CHEK1 CHUK CKS1B COMMD1 COPS2 COPS5 COPS6 COPS8 DLEU2 E2F1 FBH1 FBXO25 FBXW11 FBXW2 FBXW4 FBXW7 GHR GPS1 HIPK2 KHNYN NEDD8 NFKBIA NFKBIB NFKBIE NLK NLRP3 NR1D2 PPP1CA PRKN PRPF40A PSMB4 PSMD4 PTTG1 RAC2 RANBP2 RBX1 RICTOR RNF7 SENP8 SKP1 SKP2 SMAD3 THRA TRIM21 UBC UBE2E3 UBE2F UBE2M ZC3HC1	9 interacting genes: APP BCL11A CTDSP1 CTDSP2 CUL1 SKP1 TRAF1 TRAF2 WEE1
Entrez ID		8454	83461
HPRD ID		04389	09670
Ensembl ID		ENSG00000055130	ENSG00000111665
Uniprot IDs		A0A090N7U0 B3KTW0 Q13616	F5GX58 F8WDL1 J3KMY0 Q99618
PDB IDs		1LDJ 1LDK 1U6G 3RTR 3TDU 3TDZ 4F52 4P5O 5V89
Enriched GO Terms of Interacting Partners?
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