PCGF5 and CBX8

Number of citations of the paper that reports this interaction (PubMedID 26496610)
285

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)

		PCGF5	CBX8
Description		polycomb group ring finger 5	chromobox 8
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GO Annotations	Cellular Component	X Chromosome Nucleus Nucleoplasm Centrosome PcG Protein Complex PRC1 Complex	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding	Single-stranded RNA Binding Protein Binding Methylated Histone Binding Ubiquitin-protein Transferase Activator Activity
	Biological Process	Histone H2A-K119 Monoubiquitination Positive Regulation Of Transcription By RNA Polymerase II Inactivation Of X Chromosome By Genetic Imprinting	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation Histone Ubiquitination Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Chronotype ( 30696823) Height ( 28552196)	General risk tolerance (MTAG) ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		9 interacting genes: CBX6 CBX7 CBX8 PCGF1 PHC2 PRMT6 TRAF2 TRIM8 UBE2D3	36 interacting genes: BMI1 CALCOCO2 CCDC136 CCDC57 EEF1G FSD2 GOLGA2 GPRASP2 H3-4 HAP1 HMBOX1 IKZF1 KAT5 KAT7 KCTD9 KIFC3 KRT40 LZTS2 MID2 MLLT1 MLLT3 MTUS2 PAXIP1 PCGF5 PNMA2 RING1 RPGRIP1 SETDB1 SOX5 TFCP2 TRAF2 TSGA10 UNC119 USP11 USP7 ZBTB14
Entrez ID		84333	57332
HPRD ID		17825	13006
Ensembl ID		ENSG00000180628	ENSG00000141570
Uniprot IDs		Q86SE9	Q9HC52
PDB IDs		4S3O	2N4Q 3I91 5EQ0
Enriched GO Terms of Interacting Partners?
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