CHD6 and NFE2L2

Number of citations of the paper that reports this interaction (PubMedID 16314513)
64

Data Source:
HPRD (in vivo, two hybrid)

		CHD6	NFE2L2
Description		chromodomain helicase DNA binding protein 6	nuclear factor, erythroid 2 like 2
Image
GO Annotations	Cellular Component	Nucleoplasm	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Protein-DNA Complex
	Molecular Function	Transcription Cofactor Binding DNA Binding DNA Helicase Activity ATP Binding DNA-dependent ATPase Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding Transcription Cofactor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Chromatin Organization Viral Process DNA Duplex Unwinding Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Aging Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Viral Process Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Redox Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Aflatoxin Catabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Glutathione Biosynthetic Process Cellular Response To Angiotensin Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Diastolic blood pressure ( 27841878) Gastric adenocarcinoma (histologically verified) ( 26098866) Hippocampal atrophy ( 22745009) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Refractive astigmatism ( 30306274) Systolic blood pressure ( 27841878) Total cholesterol levels ( 30275531) Verbal declarative memory ( 25648963) Waist circumference ( 31170924)	Estimated glomerular filtration rate ( 31152163 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		6 interacting genes: ARAF ATXN1L H3-4 NFE2L2 TOLLIP ZFYVE9	34 interacting genes: ATF4 BPTF CASP1 CASP3 CDH1 CHD6 COPS7A CREB3 CREBBP DCAF11 EIF2AK3 GSK3B JUN JUND KEAP1 KPNA3 MAFF MAFG MAFK MAPK7 NCOR2 NFE2 NFE2L3 PMF1 PPARG PRKCA PRKCD RBMX SUMO1 SUMO2 TNNT1 TRIM24 UBE2E2 WAC
Entrez ID		84181	4780
HPRD ID		13049	02732
Ensembl ID		ENSG00000124177	ENSG00000116044
Uniprot IDs		Q8TD26	Q16236
PDB IDs		2EPB	2FLU 2LZ1 3ZGC 4IFL 5WFV
Enriched GO Terms of Interacting Partners?
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