ITCH and CXCR4

  • Number of citations of the paper that reports this interaction (PubMedID 19116316)
  • 43
  • Data Source:
  • BioGRID (affinity chromatography technology, pull down, biochemical, affinity chromatography technology)

ITCH

CXCR4

Description itchy E3 ubiquitin protein ligase C-X-C motif chemokine receptor 4
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Interacting Genes 103 interacting genes: ARHGEF7 ARID1A ARRB2 ARRDC3 ATN1 BECN1 BIN1 BRAF CBL CBLC CDC34 CEP250 CPSF6 CPSF7 CSNK2A1 CXCR4 CYLD DAZAP1 DTX1 DTX3L ERBB4 EWSR1 FYN GLIS3 GNAI2 HNRNPL HNRNPUL1 JUN JUNB KPNB1 LAPTM5 LITAF LRRK1 MAP2K4 MAPK8 MARVELD2 MLANA N4BP1 NDFIP1 NDFIP2 NEDD9 NFE2 NOTCH1 NUDT21 NUMB PABPC1 PACSIN1 POLR2A POLR2B POLR2C POLR2E POU5F1 PRKACA RASSF5 RIPK1 RNF11 RPAP2 RPAP3 SCNN1A SCNN1B SF1 SGK3 SH3GL1 SH3GL2 SMAD2 SMAD3 SMARCC1 SMARCC2 SMARCE1 SMN1 SNX9 SPART STAM2 SUFU TAB1 TP63 TP73 TRPC4 TRPV1 TRPV4 TXNIP UBAP2 UBAP2L UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J2 UBE2K UBE2L3 UBE2M UBE2O UBE2Q1 UBE2Q2 UBE2R2 URI1 WBP2 34 interacting genes: ARRB2 ATP13A2 B2M CCR5 CD4 CTSG CXCL12 DPP4 DUXAP9 ELANE GNA13 GNAI1 GRK3 HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC RNF113A SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID 83737 7852
HPRD ID 07565 01217
Ensembl ID ENSG00000078747 ENSG00000121966
Uniprot IDs A0A590UJQ1 Q96J02 A0A0U3FJG0 A0A0U3GXA9 P61073
PDB IDs 2DMV 2KYK 2NQ3 2P4R 2YSF 3TUG 4ROF 5C7M 5CQ2 5DWS 5DZD 5SXP 2K03 2K04 2K05 2N55 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS
Enriched GO Terms of Interacting Partners?
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