CASP1 and BCAP31

Number of citations of the paper that reports this interaction (PubMedID 9334338)
72

Data Source:
HPRD (in vivo, in vitro)

		CASP1	BCAP31
Description		caspase 1	B cell receptor associated protein 31
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex Protease Inhibitor Complex	Cell Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Integral Component Of Plasma Membrane Membrane Clathrin-coated Vesicle Golgi Cisterna Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Perinuclear Endoplasmic Reticulum
	Molecular Function	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Kinase Binding Identical Protein Binding CARD Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding
	Biological Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Protein Autoprocessing Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Cellular Response To Interferon-gamma Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Apoptotic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Spermatogenesis Viral Process Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Protein Localization To Endoplasmic Reticulum Exit Site Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		NOD1/2 Signaling Pathway Interleukin-1 processing TP53 Regulates Transcription of Caspase Activators and Caspases The NLRP3 inflammasome The AIM2 inflammasome The IPAF inflammasome Interleukin-37 signaling Purinergic signaling in leishmaniasis infection	Apoptotic cleavage of cellular proteins Apoptotic execution phase Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Minocycline Pralnacasan LAX-101 Emricasan VX-765 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE Z-Val-Ala-Asp fluoromethyl ketone 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		42 interacting genes: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17 CARD8 CASP10 CASP14 CASP8 CAST CDK11B EGFR FGF2 HTT IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARP1 PLA2G4A PLA2G4B PRKN PSEN1 PSEN2 PYCARD RIPK2 SERPINB9 TFAP2A TIRAP VAC14	26 interacting genes: ACTG1 APP AQP2 BCAP29 BCL2 BCL2L1 CANX CASP1 CASP3 CASP8 FIS1 GPRIN2 HACD2 HLA-A IGHD KLK10 LMAN1 MSN MYH10 PLP2 SERPINF2 VAMP1 VAMP2 VAMP3 VKORC1 YWHAQ
Entrez ID		834	10134
HPRD ID		00977	02319
Ensembl ID		ENSG00000137752	ENSG00000185825
Uniprot IDs		A8K249 A8K257 P29466	P51572
PDB IDs		1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7 5FNA 5MMV 5MTK 6BZ9 6F6R	4JZL 4JZP
Enriched GO Terms of Interacting Partners?
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