CAPN2 and CDK5R1

Number of citations of the paper that reports this interaction (PubMedID 10830966)
306

Data Source:
HPRD (in vivo, in vitro)

		CAPN2	CDK5R1
Description		calpain 2	cyclin dependent kinase 5 regulatory subunit 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Mitochondrial Intermembrane Space Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Dendrite Cortical Actin Cytoskeleton Pseudopodium Neuronal Cell Body Membrane Raft Extracellular Exosome Perinuclear Endoplasmic Reticulum	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Axon Dendrite Growth Cone Neuromuscular Junction Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Intracellular Membrane-bounded Organelle Contractile Fiber Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cysteine-type Peptidase Activity Enzyme Binding Protein-containing Complex Binding	Protease Binding Protein Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Protein Kinase Binding Protein Kinase Activator Activity Ionotropic Glutamate Receptor Binding Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ephrin Receptor Binding Beta-tubulin Binding Actin Filament Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Response To Hypoxia Blastocyst Development Proteolysis Myoblast Fusion Female Pregnancy Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Extracellular Matrix Disassembly Regulation Of Interleukin-6 Production Cellular Response To Interferon-beta Response To Hydrogen Peroxide Behavioral Response To Pain Regulation Of Cytoskeleton Organization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Positive Regulation Of Neuron Death Positive Regulation Of Myoblast Fusion Positive Regulation Of Phosphatidylcholine Biosynthetic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Neuron Migration Neuron Cell-cell Adhesion G Protein-coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Neuron Differentiation Negative Regulation Of Axon Extension Positive Regulation Of Microtubule Polymerization Neuron Projection Development Activation Of Protein Kinase Activity Regulation Of Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Serine Phosphorylation Of STAT Protein Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Targeting To Membrane Regulation Of Synaptic Vesicle Cycle Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5
Drugs			Indirubin-3'-Monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Carotenoid levels (alpha-carotene) ( 28002826) Febrile seizures (MMR vaccine-related) ( 25344690) Waist circumference ( 31170924)
Interacting Genes		22 interacting genes: ATG5 ATXN3 BCL2 BID CAPNS1 CAPNS2 CASP9 CDK5R1 F2RL1 GAS2 GRK2 KNG1 MAPK1 MAPT MTDH NFKBIA NMT1 PBXIP1 PTPN1 PTPRN TNS1 ZFYVE21	30 interacting genes: ACTN1 AMPH APP BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 HSP90AA1 KRT40 KRTAP10-3 LMTK2 MTUS2 NEDD4 NES NOTCH2NLA ODF1 PAK1 SET SIAH1 STXBP1 TSC22D4 TTBK1
Entrez ID		824	8851
HPRD ID		00254	04586
Ensembl ID		ENSG00000162909	ENSG00000176749
Uniprot IDs		B4DN77 P17655 Q59EF6	Q15078 Q8N619
PDB IDs		1KFU 1KFX 2NQA	1H4L 1UNG 1UNH 1UNL 3O0G
Enriched GO Terms of Interacting Partners?
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