CAPN1 and F2R

Number of citations of the paper that reports this interaction (PubMedID 10978167)
21

Data Source:
BioGRID (imaging technique)
HPRD (in vitro)

		CAPN1	F2R
Description		calpain 1	coagulation factor II thrombin receptor
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Cell Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell Surface Platelet Dense Tubular Network Neuromuscular Junction Postsynaptic Membrane
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Receptor Catabolic Process Neutrophil Degranulation Regulation Of Catalytic Activity Mammary Gland Involution Cornification Self Proteolysis Regulation Of NMDA Receptor Activity	Activation Of MAPKK Activity Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Glomerular Filtration Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Establishment Of Synaptic Specificity At Neuromuscular Junction Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Wounding Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of JAK-STAT Cascade Homeostasis Of Number Of Cells Within A Tissue Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Platelet Dense Granule Organization Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Negative Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Common Pathway of Fibrin Clot Formation Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)
Drugs		N-[N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-Butyl]-Guanidine CBZ-LEU-LEU-TYR-CH2F (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE	Streptokinase SR-123781A Vorapaxar Thrombin
Diseases
GWAS		Urate levels ( 31578528)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Mean platelet volume ( 22139419) Platelet count ( 22139419) Platelet distribution width ( 27863252)
Interacting Genes		54 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 ELOB F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM	19 interacting genes: ARRDC3 ATP13A2 CAPN1 CHRD CTSG ELANE F2 F2RL1 GNA12 GNA13 GNA15 GNAI2 GNAT1 GPRASP1 ITGAV PDCD6IP PLG PRTN3 SNX1
Entrez ID		823	2149
HPRD ID		00253	01763
Ensembl ID		ENSG00000014216	ENSG00000181104
Uniprot IDs		B2RDI5 B4DWH5 P07384	A0A024RAP7 P25116
PDB IDs		1ZCM 2ARY	1NRN 1NRO 1NRP 1NRQ 1NRR 3BEF 3HKI 3HKJ 3LU9 3VW7
Enriched GO Terms of Interacting Partners?
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