CAMK2G and SPR

Number of citations of the paper that reports this interaction (PubMedID 11825621)
0

Data Source:
HPRD (in vitro)

		CAMK2G	SPR
Description		calcium/calmodulin dependent protein kinase II gamma	sepiapterin reductase
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection	Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity	Aldo-keto Reductase (NADP) Activity Sepiapterin Reductase Activity NADP Binding
	Biological Process	Protein Phosphorylation Protein Dephosphorylation Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Cofactor Metabolic Process Oxidation-reduction Process
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation
Drugs		Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Oxaloacetate Ion 2'-Monophosphoadenosine 5'-Diphosphoribose Biopterin N-Acetyl Serotonin
Diseases
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) FEV1 ( 30804560) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458)	Diastolic blood pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		31 interacting genes: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CHAT CREM EGFR FLNA GRIA1 GRIA4 GRIN1 GRIN2B LRRC7 MYLK PEA15 PLCB3 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 SYN1 TH TIAM1	2 interacting genes: CAMK2G YWHAQ
Entrez ID		818	6697
HPRD ID		03672	01632
Ensembl ID		ENSG00000148660	ENSG00000116096
Uniprot IDs		A0A2Q3DQE3 B3KY86 Q13280 Q13555 Q5SWX3	P35270
PDB IDs		2UX0 2V7O	1Z6Z 4HWK 4J7U 4J7X 4XWY 4Z3K 6I6C 6I6F 6I6P 6I6T 6I6V 6I79
Enriched GO Terms of Interacting Partners?
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