PLA2G12A and UMPS

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PLA2G12A	UMPS
Description		phospholipase A2 group XIIA	uridine monophosphate synthetase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Orotate Phosphoribosyltransferase Activity Orotidine-5'-phosphate Decarboxylase Activity
	Biological Process	Phosphatidic Acid Biosynthetic Process Biological_process Lipid Catabolic Process Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Arachidonic Acid Secretion	'de Novo' Pyrimidine Nucleobase Biosynthetic Process UMP Biosynthetic Process Female Pregnancy Lactation Pyrimidine Nucleobase Biosynthetic Process Cellular Response To Drug 'de Novo' UMP Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Pyrimidine biosynthesis
Drugs			6-Hydroxyuridine-5'-Phosphate
Diseases			Orotic aciduria
GWAS		Blood protein levels ( 28240269) HDL cholesterol ( 30275531) Triglycerides ( 30275531)	Coronary artery disease ( 29212778 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
Interacting Genes		9 interacting genes: DVL2 MEF2C RB1 RPS15 RPS6 TMEM37 UCK1 UMPS YWHAG	14 interacting genes: A2M CALU CASP8 CDC42EP3 DLST NOS3 PAXIP1 PIK3CA PLA2G12A PSEN1 RAD51 RB1CC1 RPS29 ZNF227
Entrez ID		81579	7372
HPRD ID		17858	02022
Ensembl ID		ENSG00000123739	ENSG00000114491
Uniprot IDs		Q542Y6 Q9BZM1	A8K5J1 P11172
PDB IDs			2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ 3EX1 3EX2 3EX3 3EX4 3EX6 3G3D 3G3M 3L0K 3L0N 3MI2 3MO7 3MW7 4HIB 4HKP
Enriched GO Terms of Interacting Partners?
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