CCDC130 and JUP

Number of citations of the paper that reports this interaction (PubMedID 22365833)
132

Data Source:
BioGRID (two hybrid, two hybrid)

		CCDC130	JUP
Description		coiled-coil domain containing 130	junction plakoglobin
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Cornified Envelope Extracellular Region Cell Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Protein-containing Complex Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Response To Virus	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cytoskeletal Anchoring At Plasma Membrane Cell Migration Keratinization Adherens Junction Organization Regulation Of Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Neutrophil Degranulation Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Positive Regulation Of DNA-binding Transcription Factor Activity Cornification Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways			Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs			Zinc
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome
GWAS			Heel bone mineral density ( 30598549 28869591)
Interacting Genes		8 interacting genes: EEF1A1 JUP NINL TRAF2 ZBTB16 ZNF165 ZNF24 ZNF572	47 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CCDC130 CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNBIP1 CTNND1 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 FER FHL2 FYN MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 SRC TBP TCF4 TCF7L2 ZFYVE9
Entrez ID		81576	3728
HPRD ID		11304	01414
Ensembl ID		ENSG00000104957	ENSG00000173801
Uniprot IDs		B7Z1U2 P13994	A0A0S2Z487 P14923
PDB IDs			3IFQ
Enriched GO Terms of Interacting Partners?
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