ADAM12 and EGF

Number of citations of the paper that reports this interaction (PubMedID 11786904)
142

Data Source:
HPRD (in vivo)

		ADAM12	EGF
Description		ADAM metallopeptidase domain 12	epidermal growth factor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane Platelet Alpha Granule Lumen Receptor Complex Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding	Ras Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity Wnt-protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Wnt-activated Receptor Activity
	Biological Process	Proteolysis Cell Adhesion Myoblast Fusion Extracellular Matrix Organization Positive Regulation Of Angiogenesis	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Angiogenesis Positive Regulation Of Receptor Internalization Platelet Degranulation Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cell Migration ERBB2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of DNA Binding Positive Regulation Of MAP Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Regulation Of JAK-STAT Cascade Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Secretion Positive Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Mammary Gland Alveolus Development Membrane Organization ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of Cholesterol Efflux Positive Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Regulation Of Protein Localization To Cell Surface Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Motility
Pathways		Signaling by EGFR Invadopodia formation	Platelet degranulation Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants
Drugs			Sucralfate Alpha-Aminobutyric Acid Tesevatinib
Diseases			Gastric cancer
GWAS		Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 27021288) Placental abruption ( 29884306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)	Albumin-globulin ratio ( 29403010) Blood protein levels ( 30072576 29875488) Hair morphology ( 19896111) Mean corpuscular volume ( 29403010) Non-albumin protein levels ( 29403010) Platelet count ( 29403010 27863252) Plateletcrit ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		12 interacting genes: ACTN2 EGF FSTL3 GRB2 IGFBP3 IGFBP5 PACSIN3 PIK3R1 SH3D19 SRC TUBGCP2 YES1	13 interacting genes: ADAM12 CPM DUSP3 EGFR ERBB2 ERBB3 GRB2 GRK2 LMNA NRG1 PIK3R1 PIK3R2 VTN
Entrez ID		8038	1950
HPRD ID		04092	00578
Ensembl ID		ENSG00000148848	ENSG00000138798
Uniprot IDs		A8K6G4 O43184 U5NE98	P01133
PDB IDs			1IVO 1JL9 1NQL 1P9J 2KV4 3NJP
Enriched GO Terms of Interacting Partners?
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