LRRC8E and TRIM2

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		LRRC8E	TRIM2
Description		leucine rich repeat containing 8 VRAC subunit E	tripartite motif containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Ion Channel Complex	Cytoplasm
	Molecular Function	Volume-sensitive Anion Channel Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Inorganic Anion Transport Aspartate Transmembrane Transport Transmembrane Transport Cellular Response To Osmotic Stress Anion Transmembrane Transport	Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Apoptotic Process
Pathways		Miscellaneous transport and binding events	Interferon gamma signaling
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS			HDL cholesterol ( 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Multiple sclerosis ( 21654844)
Interacting Genes		3 interacting genes: FBXO7 LNX2 TRIM2	25 interacting genes: BCL2L11 CDK20 CIB3 DTNBP1 GJB5 LRRC8E MNAT1 MYO5A OTUB2 SIRPA TNFAIP3 TNIK TRIM8 UBAC1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2U UBE2W
Entrez ID		80131	23321
HPRD ID		08670	10279
Ensembl ID		ENSG00000171017	ENSG00000109654
Uniprot IDs		Q6NSJ5	Q9C040
PDB IDs
Enriched GO Terms of Interacting Partners?
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