GALNT12 and MUC5AC

Number of citations of the paper that reports this interaction (PubMedID 12135769)
19

Data Source:
BioGRID (enzymatic study)

		GALNT12	MUC5AC
Description		polypeptide N-acetylgalactosaminyltransferase 12	mucin 5AC, oligomeric mucus/gel-forming
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Integral Component Of Membrane	Extracellular Space Cytoplasm Golgi Lumen Plasma Membrane Extracellular Exosome Mucus Layer
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Carbohydrate Binding Metal Ion Binding	Extracellular Matrix Structural Constituent
	Biological Process	O-glycan Processing	Stimulatory C-type Lectin Receptor Signaling Pathway O-glycan Processing Phosphatidylinositol-mediated Signaling
Pathways		Defective GALNT12 causes colorectal cancer 1 (CRCS1) O-linked glycosylation of mucins	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
Drugs
Diseases
GWAS		FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)	Asthma (adult onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		5 interacting genes: APP MUC1 MUC2 MUC5AC MUC7	2 interacting genes: GALNT12 GALNT14
Entrez ID		79695	4586
HPRD ID		13561
Ensembl ID		ENSG00000119514	ENSG00000215182
Uniprot IDs		Q8IXK2	P98088
PDB IDs		6PXU	5AJN 5AJO 5AJP
Enriched GO Terms of Interacting Partners?
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