BRCC3 and IFNAR1

Number of citations of the paper that reports this interaction (PubMedID 24075985)
25

Data Source:
BioGRID (enzymatic study)

		BRCC3	IFNAR1
Description		BRCA1/BRCA2-containing complex subunit 3	interferon alpha and beta receptor subunit 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol BRCA1-A Complex BRISC Complex	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Enzyme Regulator Activity Polyubiquitin Modification-dependent Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Metal Ion Binding Lys63-specific Deubiquitinase Activity	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding
	Biological Process	DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Response To X-ray Response To Ionizing Radiation Protein Deubiquitination Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cell Division Protein K63-linked Deubiquitination Histone H2A K63-linked Deubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint	JAK-STAT Cascade Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling
Drugs		Zinc	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant Natural alpha interferon omega interferon
Diseases
GWAS		Venous thromboembolism ( 31676865)	Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		9 interacting genes: BRCA1 FANCG IFNAR1 NUMA1 SNAPC5 SUMO2 UBC UBE2D1 UIMC1	24 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70
Entrez ID		79184	3454
HPRD ID		06465	00126
Ensembl ID		ENSG00000185515	ENSG00000142166
Uniprot IDs		P46736	A0A494C0E2 P17181
PDB IDs		6H3C 6R8F	3S98 3SE3 3SE4 4PO6
Enriched GO Terms of Interacting Partners?
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