TUBA1A and S100A9

Number of citations of the paper that reports this interaction (PubMedID 15331440)
79

Data Source:
BioGRID (pull down)

		TUBA1A	S100A9
Description		tubulin alpha 1a	S100 calcium binding protein A9
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Neuromuscular Junction Cytoplasmic Ribonucleoprotein Granule Myelin Sheath Membrane Raft Recycling Endosome Extracellular Exosome	Extracellular Region Extracellular Space Cell Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Junction Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Antioxidant Activity Toll-like Receptor 4 Binding Arachidonic Acid Binding RAGE Receptor Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoskeleton-dependent Intracellular Transport Regulation Of Synapse Organization Cell Division Ciliary Basal Body-plasma Membrane Docking	Cytokine Production Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Autophagy Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Cell-cell Signaling Positive Regulation Of Neuron Projection Development Antimicrobial Humoral Response Positive Regulation Of Cell Growth Neutrophil Chemotaxis Sequestering Of Zinc Ion Chemokine Production Peptidyl-cysteine S-trans-nitrosylation Modification Of Morphology Or Physiology Of Other Organism Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Aggregation Cellular Oxidant Detoxification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins	RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins
Drugs		Albendazole Vinblastine Mebendazole Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Artenimol Phenethyl Isothiocyanate	Calcium Zinc
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Composite immunoglobulin trait (IgG/IgM) ( 28628107)	Asthma ( 31619474) Matrix metalloproteinase-8 levels ( 29212897)
Interacting Genes		61 interacting genes: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CEP20 CLIP1 CNP CPEB2 CXCR1 CYLD DAG1 DUSP23 EGFR EML1 GEMIN7 GRM7 GSK3B GZMB HDAC6 HTRA2 KEL KPNB1 LRRK2 MAP2 MAP7D3 MAPK6 MAPRE1 MAX MX1 MYC NFATC1 NUDT3 PAFAH1B1 PLA2G7 S100A8 S100A9 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPART STARD13 STK11 SYK TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70	9 interacting genes: CDC42 EGFR MAPK14 NCF2 PTEN S100A8 TUBA1A TUBB USP13
Entrez ID		7846	6280
HPRD ID		03959	00472
Ensembl ID		ENSG00000167552	ENSG00000163220
Uniprot IDs		Q71U36	P06702
PDB IDs		5JCO 6J8F	1IRJ 1XK4 4GGF 4XJK 5I8N 5W1F 6DS2
Enriched GO Terms of Interacting Partners?
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